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FITC Rat Anti-Mouse CD172a (SIRPα) Antibody (S-R713)

FITC Rat Anti-Mouse CD172a (SIRPα) Antibody (S-R713)

货号: S0B5184
价格: 380
规格: 20T
介绍: -
其他: -
产品规格
  • 宿主来源

    Rat
  • 抗原名称

    CD172a (SIRPα)
  • 分子别名

    Tyrosine-protein phosphatase non-receptor type substrate 1; SHP substrate 1; SHPS-1; Brain Ig-like molecule with tyrosine-based activation motifs (Bit); CD172 antigen-like family member A; Inhibitory receptor SHPS-1; MyD-1 antigen; Signal-regulatory protein alpha-1 (Sirp-alpha-1; mSIRP-alpha1); p84; Bit; Myd1; Ptpns1; Shps1; Sirp; Sirpa
  • 细胞定位

    Membrane
  • Accession

    P97797
  • 克隆号

    S-R713
  • 抗体类型

    Rat mAb
  • 抗体同种型

    IgG1,k
  • 应用

    FCM
  • 反应种属 ?

    Ms
  • 阳性样本

    BALB/c mouse bone marrow
  • 纯化方式

    Protein G
  • 浓度

    50 μg/ml
  • 标记

    FITC
  • 性状

    Liquid
  • 缓冲体系

    PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300

  • 储存条件

    12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
稀释度
应用 稀释度 推荐种属
FCM 5μl per million cells in 100μl volume Ms
背景介绍
  • CD172a, also known as SIRP alpha (signal-regulatory protein alpha), is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily. It is expressed on cells of myeloid origin, including monocytes, macrophages, dendritic cells, and granulocytes, but not on T and B lymphocytes. SIRP alpha plays a crucial role in immune regulation by interacting with its ligand, CD47, which is widely expressed on various cell types, including cancer cells. This interaction transmits a "do not eat me" signal to prevent phagocytosis of healthy cells and is involved in processes like dendritic cell-mediated T cell activation and neutrophil migration. Additionally, SIRP alpha has regulatory effects on cellular responses induced by growth factors, insulin, and oncogenes, and it is implicated in both physiological and pathological processes, such as cancer progression.

  • 流式分析

    • Flow cytometric analysis of CD172a (SIRPα) expression on BALB/c mouse bone marrow. BALB/c mouse bone marrow was stained with Brilliant Violet 421™ Rat Anti-Mouse CD11b Antibody and either FITC Rat IgG1, κ Isotype Control (Left panel) or SDT FITC Rat Anti-Mouse CD172a (SIRPα) Antibody (Right panel) at 5μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.