PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 5μl per million cells in 100μl volume | Ms |
CD21 (CR2) and CD35 (CR1) are key complement receptors predominantly expressed on B cells and follicular dendritic cells (FDCs). CD21, also known as the C3d receptor, binds to complement fragments like C3d and iC3b, playing a crucial role in B cell activation and regulation of immune responses. It also serves as the receptor for Epstein-Barr virus (EBV) on B cells. CD35, on the other hand, binds to C3b and C4b, facilitating phagocytosis and immune complex clearance. It helps in the activation of B cells and regulation of complement activity. Both receptors are involved in antigen presentation and immune complex internalization, contributing to both innate and adaptive immune responses.
Flow cytometric analysis of Mouse CD21/CD35 expression on BALB/c mouse splenocytes. BALB/c mouse splenocytes were stained with Brilliant Violet 421™ Rat Anti-Mouse CD19 Antibody and either Alexa Fluor® 647 Rat IgG2a, κ Isotype Control (Left panel) or SDT Alexa Fluor® 647 Rat Anti-Mouse CD21/CD35 antibody (Right panel) at 5μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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