PBS, 1% BSA, 0.3% Proclin 300
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 5μl per million cells in 100μl volume | Hu |
CD62L, also known as L-selectin, is a type-I transmembrane glycoprotein and cell adhesion molecule belonging to the selectin family, primarily expressed on the surface of leukocytes, including T cells, B cells, and natural killer cells. It plays a crucial role in leukocyte homing and immune cell localization by mediating the initial rolling and adhesion of white blood cells to endothelial cells during inflammation. CD62L is also a marker for central memory T cells, which have a higher expression level of this molecule, allowing them to quickly respond to antigen re-exposure. Additionally, CD62L is involved in the regulation of immune cell distribution in tissues, impacting the strength and duration of immune responses. In cancer therapy, manipulating CD62L expression can enhance T cell infiltration into the tumor microenvironment, improving the efficacy of immunotherapy.
Flow cytometric analysis of Human CD62L expression on human PBMC (human peripheral blood mononuclear cells). Human PBMC were stained with Brilliant Violet 421™ Mouse Anti-Human CD4 Antibody and either APC Mouse IgG1, κ Isotype Control (Left panel) or SDT APC Mouse Anti-Human CD62L Antibody (Right panel) at 5μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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