PBS pH7.4
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 1:200 | Ms |
Folate receptor 4 (FR4), also known as FOLR4, is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein belonging to the folate receptor family. It is primarily expressed in the immune system, particularly in regulatory T cells (Tregs) and certain B cell subsets. The function of FR4 has not been fully elucidated, but studies suggest it may play a role in immune regulation and cell signaling. Unlike other members of the family (e.g., FRα, FRβ), FR4 has a lower affinity for folate, indicating it may have unique biological functions. Additionally, FR4 expression is associated with certain cancers and autoimmune diseases, potentially serving as a diagnostic marker or therapeutic target. Research is ongoing to explore its specific mechanisms and clinical applications.
Flow cytometric analysis of BALB/c mouse splenocytes labelling Mouse FR4 antibody at 1/200 (1 μg) dilution/ (Right panel) compared with a Rat IgG1, κ Isotype Control / (Left panel). Goat Anti-Rat IgG Alexa Fluor® 647 was used as the secondary antibody. Cells were stained with CD4 - APC/Cy7 Antibody separately.
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