PBS, 1% BSA, 0.3% Proclin 300
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 5μl per million cells in 100μl volume | Hu |
CD42b, also known as platelet glycoprotein Ib alpha chain (GPIbα), is a type I transmembrane glycoprotein with a molecular weight of approximately 145 kDa. It is encoded by the GP1BA gene and primarily expressed on the surface of platelets and megakaryocytes. CD42b forms a complex with other proteins, including CD42c (GPIbβ), CD42a (GPIX), and CD42d (GPV), which is essential for platelet adhesion and aggregation. This complex plays a crucial role in hemostasis by binding to von Willebrand factor (vWF), facilitating platelet attachment to the subendothelium at sites of vascular injury. Mutations or deficiencies in CD42b are associated with Bernard-Soulier syndrome, a rare bleeding disorder characterized by large platelets and impaired platelet function.
Flow cytometric analysis of Human CD42b expression on human PBMC (human peripheral blood mononuclear cells). Human PBMC were stained with APC Mouse Anti-Human CD41 Antibody and either Phycoerythrin Mouse IgG1, κ Isotype Control (Left panel) or SDT PE Mouse Anti-Human CD42b Antibody (Right panel) at 5μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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