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Ferritin Heavy Chain Recombinant Rabbit mAb

Ferritin Heavy Chain Recombinant Rabbit mAb

货号: S0B1419
价格: 600
规格: 25μl
介绍: -
其他: -
产品规格
  • 宿主来源

    Rabbit
  • 抗原名称

    Ferritin Heavy Chain
  • 分子别名

    FTH1; FTH; FTHL6; OK/SW-cl.84; PIG15; Ferritin heavy chain; Ferritin H subunit; Cell proliferation-inducing gene 15 protein
  • 免疫原

    Synthetic Peptide
  • 细胞定位

    Lysosome, Cytoplasm
  • Accession

    P02794
  • 抗体类型

    Recombinant mAb
  • 抗体同种型

    IgG
  • 应用

    ICC, WB
  • 反应种属 ?

    Hm, Hu, Ms, Rt
  • 阳性样本

    K562, CHO-K1, HeLa, mouse liver, rat liver
  • 纯化方式

    Protein A
  • 标记

    Unconjugated
  • 性状

    Liquid
  • 缓冲体系

    50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

  • 储存条件

    12 months from date of receipt / reconstitution, -20 °C as supplied

稀释度
应用 稀释度
WB 1:500-1:1000
ICC 1:50-1:200
背景介绍
  • Ferritin Heavy Chain (FTH1) is a subunit of the iron storage protein Ferritin, primarily responsible for the oxidation and storage of iron ions to maintain cellular iron homeostasis and prevent iron-mediated oxidative damage. FTH1 possesses ferroxidase activity, enabling it to oxidize toxic ferrous iron (Fe²⁺) into stable ferric iron (Fe³⁺) and store it within the Ferritin protein shell. It plays a critical role in regulating iron metabolism, antioxidant stress, and cellular protection, with its expression modulated by iron levels, oxidative stress, and inflammatory signals. Dysfunction of FTH1 is associated with various diseases, including neurodegenerative disorders, cancer, and iron overload conditions. Additionally, FTH1 is involved in immune regulation and apoptosis processes.

  • 免疫印迹

    • WB result of Ferritin Heavy Chain Recombinant Rabbit mAb
      Primary antibody: Ferritin Heavy Chain Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: K562 whole cell lysate 20 µ
      Lane 2: CHO-K1 whole cell lysate 20 µg
      Lane 3: HeLa whole cell lysate 20 µg
      Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 21 kDa
      Observed MW: 21 kDa

    • WB result of Ferritin Heavy Chain Recombinant Rabbit mAb
      Primary antibody: Ferritin Heavy Chain Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: mouse liver lysate 20 µg
      Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 21 kDa
      Observed MW: 21 kDa

  • 免疫细胞化学

    • Immunocytochemistry analysis of Ferritin(green) in Hela using Ferritin antibody,and DAPI(blue).