PBS pH7.4
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 1:200 | Hu |
CD134, also known as OX40 or tumor necrosis factor receptor superfamily member 4 (TNFRSF4), is a type 1 transmembrane glycoprotein and a secondary co-stimulatory immune checkpoint molecule involved in long-term T cell immunity. It is transiently expressed on activated CD4+ and CD8+ T cells after T cell receptor (TCR) ligation. The interaction between CD134 and its ligand, OX40L, enhances T cell activation, proliferation, survival, and cytokine production. CD134 is crucial for maintaining an immune response beyond the initial activation phase and is being investigated as a target in cancer immunotherapy, autoimmune disease modulation, and vaccine development.
Unstimulated / (Left panel) and 10 μg/ml phytohemagglutinin (PHA)-stimulated (2 days) / (Right panel) peripheral blood mononuclear cells were stained with Human CD134 at 1/200 dilution (1 μg) / (Right panel). Goat Anti-Mouse IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD3 - Alexa Fluor® 647 antibody separately.
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