PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 5μl per million cells in 100μl volume | Rt |
CD11b and CD11c are integral components of the integrin family, which are heterodimeric transmembrane glycoproteins involved in cell adhesion and immune responses. CD11b, also known as integrin alpha M (ITGAM) or Mac-1, pairs with CD18 to form complement receptor 3 (CR3), playing a crucial role in mediating the uptake of complement-coated particles and pathogens. It is expressed on various immune cells, including macrophages, monocytes, granulocytes, and NK cells. Similarly, CD11c, also called integrin alpha X (ITGAX), forms complement receptor 4 (CR4) with CD18 and is involved in similar adhesive interactions and phagocytosis. Both CD11b and CD11c are commonly used as markers for immune cells, with CD11b/c antibodies often employed in research to identify microglia in the brain and other immune cells.
Flow cytometric analysis of Rat CD11b/c expression on Lewis Rat splenocytes. Lewis Rat splenocytes were stained with Brilliant Violet 605™ Mouse Anti-Rat CD3 Antibody and either Pacific Blue Mouse IgG2a, κ Isotype Control (Left panel) or SDT Pacific Blue Mouse Anti-Rat CD11b/c Antibody (Right panel) at 5μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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