PBS, 1% BSA, 0.3% Proclin 300
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 5μl per million cells in 100μl volume | Hu |
CD59, also known as membrane inhibitor of reactive lysis (MIRL) or protectin, is a glycosylphosphatidylinositol (GPI)-anchored membrane protein that plays a crucial role in regulating the complement system, an essential part of the innate immune response. It is widely expressed on various human cells and tissues, including erythrocytes, leukocytes, fibroblasts, and epithelial cells. The primary function of CD59 is to inhibit the formation of the membrane attack complex (MAC), thereby preventing complement-mediated cell lysis. This protective mechanism is vital for maintaining cell integrity and preventing excessive immune-mediated damage.
Flow cytometric analysis of Human CD59 expression on human peripheral blood cells. Human peripheral blood cells were stained with either APC Mouse IgG2a Isotype Control (Black line histogram) or SDT APC Mouse Anti-Human CD59 Antibody (Red line histogram) at 5μl/test, cells without incubation with primary antibody and secondary antibody (Blue line histogram) was used as unlabelled control. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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