PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 5μl per million cells in 100μl volume | Hu |
CD196, also known as CCR6, is a seven-transmembrane G protein-coupled receptor belonging to the beta-chemokine receptor family. It is expressed on B cells, subsets of T cells, dendritic cells, natural killer cells, and Langerhans cells. CD196 binds to its ligand CCL20 (MIP-3α) and plays a key role in regulating the migration and recruitment of immune cells, particularly in inflammatory and immune responses. Additionally, CD196 is involved in the differentiation of Th17 cells and the development of regulatory T cells (CD4+FoxP3+). In pathological contexts, CD196 is associated with various diseases, including autoimmune conditions such as rheumatoid arthritis and inflammatory bowel disease, as well as certain cancers.
Flow cytometric analysis of Human CD196 expression on human PBMC (human peripheral blood mononuclear cells). Human PBMC were stained with Brilliant Violet 421™ Mouse Anti-Human CD19 Antibody and either FITC Mouse IgG1, κ Isotype Control (Left panel) or SDT FITC Mouse Anti-Human CD196 Antibody (Right panel) at 5μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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