PBS pH7.4
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 1:2000 | Hu |
CD278, also known as ICOS (inducible T-cell costimulator), is a costimulatory receptor belonging to the CD28 family, mainly expressed on activated CD4 and CD8 T cells, and weakly expressed on naïve T cells. It is a type-1 transmembrane molecule with a single Ig V-like domain, a transmembrane region of 23 amino acids, and a cytoplasmic domain of 35 amino acids. Structurally, it is similar to CD28 and CTLA-4 but lacks the MYPPPY motif found in CD28, which is critical for binding to B7-1 and B7-2. ICOS plays a crucial role in T cell activation and differentiation, particularly in the development and maintenance of T follicular helper (Tfh) cells. It is also involved in the regulation of cytokine production and cell motility, promoting the migration of T cells to the follicle. Additionally, ICOS signaling can induce the expression of CXCR5 and Bcl6, and suppress the expression of CCR7, PSGL-1, and CD62L through the factor KLF2.
Unstimulated / (Left panel) and 10μg/ml phytohemagglutinin (PHA)-stimulated (2 days) / (Right panel) peripheral blood mononuclear cells were stained with Human CD278 at 1/2000 dilution (0.1 μg) / (Right panel). Goat Anti - Armenian Hamster IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD3 - Brilliant Violet 421™ antibody separately.
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