PBS pH7.4, 0.03% Proclin 300
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 5μl per million cells in 100μl volume | Ms |
NK1.1/CD161, also known as KLRB1 or NKR-P1A, is a type II transmembrane C-type lectin-like receptor expressed as a disulfide-linked homodimer on the cell membrane. It is predominantly found on the majority of natural killer (NK) cells and subsets of peripheral T cells, including both CD4+ and CD8+ T cells, particularly those with a "memory" antigenic phenotype. The expression of CD161 is specifically upregulated by IL-12 and is associated with the cytotoxic function of CD16+ NK cells. Functionally, CD161 plays a role in modulating the activation and proliferation of NK cells, inducing interferon-γ production, and releasing cytotoxic granules. When CD161 binds to its ligand LLT1, it inhibits NK cell cytotoxicity and cytokine secretion.
Flow cytometric analysis of Mouse NK1.1/CD161 expression on C57BL/6 mouse splenocytes. C57BL/6 mouse splenocytes were stained with Phycoerythrin Rat Anti-Mouse CD49b Antibody and either Biotin Isotype Control (Left panel) or SDT Biotin Rabbit Anti-Mouse NK1.1/CD161 Antibody (Right panel) at 5μl/test followed by Sav-iFluor 488. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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