PBS pH7.4
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 1:2000 | Hu |
CD61, also known as integrin β3 or GPIIIa, is a membrane glycoprotein that forms heterodimeric complexes with other integrins, such as CD41 (forming the GPIIb/IIIa complex) and CD51 (forming the αvβ3 integrin). It is primarily expressed on platelets, megakaryocytes, endothelial cells, osteoclasts, and some tumor cells. The CD61/CD41 complex is crucial for platelet aggregation and blood clotting through interactions with fibrinogen and von Willebrand factor. Additionally, CD61 plays a role in cell adhesion, migration, and invasion in various physiological and pathological processes, including tumor metastasis and viral infections. In clinical settings, CD61 is used as a biomarker for identifying platelets and megakaryocytes, and its upregulation in tumors is associated with poor prognosis in several cancers.
Flow cytometric analysis of human PBMC (human peripheral blood mononuclear cells) labelling Human CD61 antibody at 1/2000 (0.1 μg) dilution/ (Right panel) compared with a Mouse IgG1, κ Isotype Control / (Left panel). Goat Anti-Mouse IgG Alexa Fluor® 647 was used as the secondary antibody. Then cells were stained with CD62P - Alexa Fluor® 488 Antibody separately.
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