您现在的位置：首页 - 产品中心 - 免疫学 - 抗体

Galectin-4 Protein, Human

货号: UA010183

价格: 3200

规格: 100μg

介绍: -

其他: -

产品规格

物种

Human
分子别名

Antigen NY-CO-27, GAL4, gal-4, galectin 4, Galectin4, L-36 lactose-binding protein, L36LBP, Lactose-binding lectin 4, lectin galactoside-binding soluble 4, LGALS4
Accession

P56470
表达序列

Ala2-Ile323
表达宿主

E.coli
分子量

36kDa
纯度

>95% by SDS-PAGE
内毒素含量

<0.1EU/μg
标记

Unconjugated
性状

Lyophilized Powder
缓冲体系

250mM Tris, 150mM NaCl, 3mM DTT, pH8.0
溶解方法

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
文献引用

1、Poland P A. et al. (2022) Cloning, Expression, and Purification of Galectins for In Vitro Studies. Methods in Molecular Biology. 2442: 41-54.
2、Rustiguel J K. et al. (2016) Recombinant expression, purification and preliminary biophysical and structural studies of C-terminal carbohydrate recognition domain from human galectin-4. 118: 39-48.
3、Stancic M. et al. (2012) Galectin-4, a Novel Neuronal Regulator of Myelination. GLIA. 60(6): 919-935.

背景介绍

Galectins are best known for their ability to bind glycoconjugates containing β-galactose, but classification of these small proteins within the galectin family is also defined by amino acid homology within structural domains and exon/intron junctions within genes. Galectin-4 (Gal4), a tandem-repeat type galectin, is expressed in healthy epithelium of the gastrointestinal tract. Altered levels of Gal4 expression are associated with different types of cancer, suggesting its usage as a diagnostic marker as well as target for drug development. The functional data available for this class of proteins suggest that the wide spectrum of cellular activities reported for Gal4 relies on distinct glycan specificity and structural characteristics of its two carbohydrate recognition domains. Gal4, a tandem-repeat-type lectin with affinity to sulfatide and non-sialylated termini of N-glycans, has the ability to regulate adhesion of cells to ECM components and is also involved in polarized membrane trafficking.