Leu20-Pro219, with C-terminal Avi&8*His tag LFTVTVPKELYIIEHGSNVTLECNFDTGSHVNLGAITASLQKVENDTSPHRERATLLEEQLPLGKASFHIPQVQVRDEGQYQCIIIYGVAWDYKYLTLKVKASYRKINTHILKVPETDEVELTCQATGYPLAEVSWPNVSVPANTSHSRTPEGLYQVTSVLRLKPPPGRNFSCVFWNTHVRELTLASIDLQSQMEPRTHPGGGSGLNDIFEAQKIEWHEHHHHHHHH
33-43kDa
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
1. Masatsugu Kojima , Satoshi Murata, Eiji Mekata, Katsushi Takebayashi, Elizabeth M Jaffee, Tohru Tani Fusion protein of mutant B7-DC and Fc enhances the antitumor immune effect of GM-CSF-secreting whole-cell vaccine. J Immunother (2014). 37(3):147-54.
B7-DC [also known as programmed death ligand 2 (PD-L2)] is a costimulatory molecule expressed predominantly on dendritic cells (DCs) and macrophages. In addition to its coinhibitory receptor, programmed death receptor 1 (PD-1), evidence suggests that B7-DC interacts with an unidentified costimulatory receptor on T cells. B7-DC mutants with selective binding capacity for the costimulatory receptor may be effective in stimulating antitumor immune responses, while avoiding the inhibitory effects of PD-1.
2μg (R: reducing conditions, N: non-reducing conditions).
Immobilized Biotinylated PD-L2 Avi&His Tag Protein, Human (Cat. No. UA010568) at 2 μg/mL on Streptavidin precoated (0.5μg/well) plate, can bind PD-1 Fc Chimera Protein, Human (Cat. No. UA010002) with EC50 of 12.38-18.46ng/ml.
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