110-120kDa
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
1、Schlessinger J. (2000) Cell Signaling by Receptor Tyrosine Kinases. Cell. 103(2): 211-225.
2、Codony-Servat J et al. (1999) Cleavage of the HER2 Ectodomain Is a Pervanadate-activable Process That Is Inhibited by the Tissue Inhibitor of Metalloproteases-1 in Breast Cancer Cells. Cancer Res. 59(6): 1196-1201.
The HER2/neu gene is one of the family of genes encoding transmembrane receptors for four growth factors, including the epidermal growth factor receptor (EGFR), HER2/neu, HER3, and HER4. The HER2/neu gene is localized on the long arm (q21) of chromosome 17. This gene codes for a 185 kDa receptor-type tyrosine protein kinase (p185 neu or c-erbB-2) similar to EGFR. This 1255 amino acid transmembrane glycoprotein is composed of three domains: an extracellular factor-binding domain, a transmembrane domain, and an intracellular domain with tyrosine kinase activity. The intracellular domain of HER2/neu has tyrosine kinase activity, which regulates cell growth and proliferation. HER2/neu is over-expressed in 20-25% of invasive breast cancers and is associated with an aggressive tumor, early relapse, and reduced survival.
Immobilized Her2 Fc Chimera Protein, Human (Cat. No. UA010197) at 2.0μg/mL (100μL/well) can bind Biotinylated Trastuzumab with EC50 of 1.89-2.32ng/mL.
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