Asn49-Ser162
12 kDa(Reducing)
＞95% by SDS-PAGE
PBS, pH7.4
Reconstitute at 0.1-1mg/ml according to the size in ultrapure water after rapid centrifugation.
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Interleukin-15 (IL-15), a cytokine discovered in 1994, supports the homeostasis of cytotoxic immune cells, exhibits a broad biological activity. IL-15 stimulate the proliferation of activated T cells as well as to facilitate the induction of cytotoxic T-lymphocytes (like CD8+), and the generation, proliferation, and activation of NK cells. Therefore, IL-15 is applied to the rapidly expanding cancer immunotherapy field combining with other agents, i.e., checkpoint inhibitors, monoclonal antibodies, chemotherapy, radiation, and chimeric antigen receptor T (CAR-T) cells, in order to target multiple mechanisms and enhance the immune response against tumors, which provides advantages to control and treat cancers.
The EC50 as determined by the dose-dependent stimulation of the proliferation of CTLL-2 was found to be <0.2ng/ml.
Immobilized IL-15, Human (Cat. No. UA040010) at 2μg/mL (100μL/well) can bind IL-15R alpha/CD215 Fc Chimera, Mouse (Cat. No. UA010314) with EC50 of 18.40-68.11 ng/mL.
Immobilized IL-15 Protein, Human (Cat. No. UA040010) at 2.0μg/mL (100μL/well) can bind IL-15R alpha/CD215 Fc Chimera Protein, Human (Cat. No. UA010309) with EC50 of 6.27-8.97ng/mL.
Anti-His antibody Immobilized on CM5 Chip captured IL-2R beta/CD122 His Tag, Human (Cat. No. UA010372), can bind IL-15, Human (Cat. No. UA040010) with an affinity constant of 19.04 nM as determined in SPR assay.
Protein A Chip captured IL-15R alpha/CD215 Fc Chimera, Human (Cat. No. UA010309), can bind IL-15, Human (Cat. No. UA040010) with an affinity constant of 4.35 nM as determined in SPR assay.
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