Ala23-Asp309, with C-terminal 8*His AEPHSLRYNLMVLSQDGSVQSGFLAEGHLDGQPFLRYDRQKRRAKPQGQWAENVLGAKTWDTETEDLTENGQDLRRTLTHIKDQKGGLHSLQEIRVCEIHEDSSTRGSRHFYYDGELFLSQNLETQESTVPQSSRAQTLAMNVTNFWKEDAMKTKTHYRAMQADCLQKLQRYLKSGVAIRRTVPPMVNVTCSEVSEGNITVTCRASSFYPRNITLTWRQDGVSLSHNTQQWGDVLPDGNGTYQTWVATRIRQGEEQRFTCYMEHSGNHGTHPVPSGKALVLQSQRTDGGGSHHHHHHHH
1． Gene ID: 4277, updated on 21-Jun-2023.
This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. Similar to classical MHC class I proteins, MICB contains three Ig-like domains (alpha 1, alpha 2, and alpha 3) in the extracellular domain (ECD), a transmembrane segment, and a carboxy-terminal cytoplasmic tail. MICB is minimally expressed on normal cells, but are frequently expressed on epithelial tumors and can be induced by bacterial and viral infections.
2μg (R: reducing conditions, N: non-reducing conditions).
Immobilized MICB His Tag, Human (Cat. No. UA010590) at 2.0μg/mL (100μL/well) can bind NKG2D/CD314 Fc Chimera, Human (Cat. No. UA010732) with EC50 of 0.48-0.61μg/mL.
Immobilized MICB His Tag, Human (Cat. No. UA010590) at 2.0μg/mL (100μL/well) can bind NKG2D/CD314 Fc Chimera, Cynomolgus/Rhesus (Cat. No. UA010739) with EC50 of 0.14-0.18 μg/mL.
Protein A Chip captured NKG2D/CD314 Fc Chimera, Human (Cat. No. UA010732), can bind MICB His Tag, Human (Cat. No. UA010590) with an affinity constant of 47.67nM as determined in SPR assay.
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