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FGF-12 Protein, Human

FGF-12 Protein, Human

货号: UA040116
价格: 620
规格: 10μg
介绍: -
其他: -
产品规格

  • 物种

    Human

  • 抗原名称

    FGF-12

  • 分子别名

    Fibroblast growth factor homologous (FHF-1), Myocyte-activating factor, FGF12B

  • Accession

    P61328-2

  • 表达序列

    Met1-Thr181

  • 表达宿主

    E.coli

  • 分子量

    21kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    20mM PB, 150mM NaCl, 1mM DTT, 1mM EDTA, pH 7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. Am J Physiol Heart Circ Physiol. 2015 Jun 15;308(12):H1463-73.

  • 稀释度

背景介绍

  • Fibroblast growth factor 12 (FGF-12), also known as fibroblast growth factor homologous factors (FHF), is cytosolic proteins that is homologous to fibroblast growth factors but is not secreted. FGF12 modulates both cardiac Na+ and Ca+ channel by binding to the conserved proximal part of the C-terminal domain of voltage-gated sodium channels Nav1.5. However, a single missense mutation in FGF12-B (Q7R-FGF12) reduced binding to the NaV1.5 C-terminus, yielding a Brugada Syndrome phenotype.

  • 生物活性JSON

    • Measured in a cell proliferation assay using NIH-3T3 mouse fibroblast cells. The EC50 for this effect is less than 5ng/ml.

  • 电泳JSON

    • 1μg (R: reducing condition, N: non-reducing condition).