Glu19-Asn247, with C-terminal Human IgG1 Fc
70-75kDa
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
1. WANG, MENGJIE, BU, JIN, ZHOU, MAOHUA, et al. CD8(+) T cells expressing both PD-1 and TIGIT but not CD226 are dysfunctional in acute myeloid leukemia (AML) patients[J]. Clinical immunology: The official journal of the Clinical Immunology Society,2018,19064-73.
DNAM-1 is a member of the Ig superfamily, encoded by a gene on human chromosome 18q22.3, is expressed by human NK cells, T cells, a subset of B cells, monocytes and platelets. Interactions between DNAM-1 on NK cells and its ligands on tumour cells augments the NK cell–mediated cytotoxicity and cytokine production. CD155 and its related family member CD112, the known ligands for DNAM-1, broadly expressed on hematopoietic, epithelial, and endothelial cells. Moreover, it was shown that the interaction of DNAM-1 with CD112 and CD155 contributes to the NK-mediated lysis of both imDCs and mDCs. Dysregulation of DNAM-1 is associated with susceptibility to juvenile idiopathic arthritis, type 1 diabetes (T1D), lupus, and rheumatoid arthritis in patients.
1ug (R: reducing conditions, N: non-reducing conditions).
Immobilized CD155/PVR His Tag, Human (Cat. No. UA010069) at 2.0μg/mL (100μL/well) can bind DNAM-1/CD226 Fc Chimera, Human (Cat. No. UA010560) with EC50 of 4.48-13.43μg/ml.
Protein A Chip captured DNAM-1/CD226 Fc Chimera, Human(Cat. No. UA010560), can bind CD155/PVR His Tag, Human(Cat. No. UA010069) with an affinity constant of 1.28μM as determined in SPR assay.
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