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FKBP12 His Tag Protein, Human

FKBP12 His Tag Protein, Human

货号: UA010605
价格: 1250
规格: 100μg
介绍: -
其他: -
产品规格

  • 物种

    Human

  • 分子别名

    FKBP-12, FKBP-1A, FKBP1, FKBP12, PKC12, PKCI2, PPIASE

  • Accession

    P62942

  • 表达序列

    Met1-Glu108, with C terminal 8*His Tag MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLEHHHHHHHH

  • 表达宿主

    E.coli

  • 分子量

    13kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. Curr Genet. 2021 Jun;67(3):383-388.
    2. Genetics. 1999 Mar;151(3):935-44.

  • 稀释度

背景介绍

  • FKBP12 associates with several large protein complexes, including the multi-drug resistance pump and the ryanodine, inositol trisphosphate (IP3)and the type I TGF-β receptor. FKBP12 was originally identifed as a FK506 binding protein. FK506 is a clinically used immunosuppressant derived from Streptomyces tsukubaensis. The FK506–FKBP12 binary complex inhibits the protein phosphatase calcineurin, thereby preventing T lymphocytes from producing interleukin-2 in mammals.

  • 电泳JSON

    • 1μg (R: reducing condition, N: non-reducing condition).