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PTK7/CCK4 His Tag Protein, Cynomolgus

货号: UA010238

价格: 2700

规格: 100μg

介绍: -

其他: -

产品规格

物种

Cynomolgus
分子别名

PTK7, CCK4, Tyrosine-protein kinase-like 7, Protein-tyrosine kinase 7, Protein-tyrosine kinase 7
Accession

A0A2K5VNI5
表达序列

Ala39-Thr712, with C-terminal His
表达宿主

HEK293
分子量

90-100kDa
纯度

>95% by SDS-PAGE
内毒素含量

<0.1EU/μg
标记

Unconjugated
标签

His Tag
性状

Lyophilized Powder
缓冲体系

PBS, pH7.4
溶解方法

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
文献引用

1、Lichtig H. et al. (2019) Ptk7 proteolytic fragment proteins function during early xenopus development. Dev Biol. 453 (1): 48-55.
2、Damelin M. et al. (2017) A ptk7-targeted antibody-drug conjugate reduces tumor-initiating cells and induces sustained tumor regressions. Sci Transl Med. 9 (372): eaag2611.
3、Berger H. et al. (2017) Ptk7 faces the wnt in development and disease. Front Cell Dev Biol. 5: 31.

背景介绍

PTK7 comprises an extracellular region with seven immunoglobulin (Ig)-like loops, a transmembrane domain, and a cytosolic region containing a defective tyrosine kinase catalytic domain. Previous studies have reported that PTK7 functions as a co-receptor in the semaphorin/plexin signaling pathway, as well as in planar cell polarity and non-canonical Wnt signaling pathways during developmental processes. Additionally, PTK7 is associated with tumorigenesis. The expression of PTK7, which is upregulated in various malignancies, is negatively correlated with disease-free survival and/or overall survival in patients with cancer. PTK7 potentiates oncogenic signaling by functioning as a co-receptor for active RPTKs, such as FGFR1. The expression of PTK7 is also upregulated in endothelial cells, especially during tube formation.