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CD155/PVR Fc Chimera Protein, Human

CD155/PVR Fc Chimera Protein, Human

货号: UA010118
价格: 2450
规格: 100μg
介绍: -
其他: -
产品规格

  • 物种

    Human

  • Accession

    P15151

  • 表达序列

    Trp21-Asn343, with C-terminal Human IgG1 Fc WPPPGTGDVVVQAPTQVPGFLGDSVTLPCYLQVPNMEVTHVSQLTWARHGESGSMAVFHQTQGPSYSESKRLEFVAARLGAELRNASLRMFGLRVEDEGNYTCLFVTFPQGSRSVDIWLRVLAKPQNTAEVQKVQLTGEPVPMARCVSTGGRPPAQITWHSDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGKNVTCKVEHESFEKPQLLTVNLTVYYPPEVSISGYDNNWYLGQNEATLTCDARSNPEPTGYNWSTTMGPLPPFAVAQGAQLLIRPVDKPINTTLICNVTNALGARQAELTVQVKEGPPSEHSGISRNGGGSGGGSPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK

  • 表达宿主

    HEK293

  • 分子量

    79-95kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    Human Fc Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 稀释度

背景介绍

  • CD155 is a member of the immunoglobulin superfamily also known as the human receptor for poliovirus (PVR). The full length (or PVR alpha isoform) is synthesized as a 417 amino acid (aa) precursor that contains a 20aa signal sequence, a 323aa extracellular region, a 24aa TM segment and a 50aa cytoplasmic tail. It has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhesion, migration and NK-cell killing, and thus efficiently prime cell-mediated tumor-specific immunity. CD155 is expressed at high levels in several human malignancies and seems to have pro tumorigenic and therapeutically attractive properties that are currently being investigated in the field of recombinant oncolytic vitro therapy. More intriguingly, PVR participates in a considerable number of immunoregulatory functions through its interactions with activating and inhibitory immune cell receptors. These functions are often modified in the tumor microenvironment, contributing to tumor immunosuppression.

  • 生物活性JSON

    • Immobilized DNAM-1/CD226 His Tag, Human (Cat. No. UA010072) at 2μg/mL (100μL/well) can bind CD155/PVR Fc Chimera, Human (Cat. No. UA010118) with EC50 of 0.317μg/ml.
    • Immobilized TIGIT His Tag, Cynomolgus (Cat. No. UA010106) at 2.5μg/mL (100μL/well) can bind CD155/PVR Fc Chimera, Human (Cat. No. UA010118) with EC50 of 1.018μg/ml
    • Immobilized TIGIT His Tag, Human (Cat. No. UA010136) at 2.5μg/ml (100μl/well) can bind CD155/PVR Fc Chimera, Human (Cat. No. UA010118) with EC50 of 0.234μg/ml.
    • Anti-His antibody Immobilized on CM5 Chip captured TIGIT His Tag, Human (Cat. No. UA010136), can bind CD155/PVR Fc Chimera, Human (Cat. No. UA010118) with an affinity constant of 0.153μM as determined in SPR assay.
    • Anti-His antibody Immobilized on CM5 Chip captured DNAM-1/CD226 His Tag, Human (Cat. No. UA010072), can bind CD155/PVR Fc Chimera, Human (Cat. No. UA010118) with an affinity constant of 0.419μM as determined in SPR assay.
    • Anti-His antibody Immobilized on CM5 Chip captured TIGIT His Tag, Cynomolgus (Cat. No. UA010106), can bind CD155/PVR Fc Chimera, Human (Cat. No. UA010118) with an affinity constant of 0.124μM as determined in SPR assay.

  • 电泳JSON

    • 1μg (R: reducing conditions, N: non-reducing conditions).