1.Ganieva U. et al. (2022) IL-22 regulates endometrial regeneration by enhancing tight junctions and orchestrating extracellular matrix. Front Immunol. 13:955576.
2.Pavlidis P. et al. (2022) Interleukin-22 regulates neutrophil recruitment in ulcerative colitis and is associated with resistance to ustekinumab therapy. Nat Commun. 13(1): 5820.
Interleukin-22(IL-22) is a member of the IL10 family of cytokines that mediate cellular inflammatory responses and functions in antimicrobial defense at mucosal surfaces and in tissue repair. This protein also has pro-inflammatory properties and plays a role in in the pathogenesis of several intestinal diseases. IL-22 has a role in the remodeling of the uterine tissue in the inflammatory environment by regulating epithelial-mesenchymal transition markers called E- and N-cadherin. Therefore, IL-22 contributes to the proper regeneration of endometrial layers after inflammation-triggered abortion. Thus, it might have a practical significance to be utilized as a treatment option postpartum (enhanced regeneration function) and in secondary infertility caused by inflammation (enhanced barrier/protector function). IL-22 is a crucial cytokine that regulates host immunity in infectious diseases, including COVID-19 (disease caused by SARS-CoV-2).
Measured by its ability to induce IL-10 secretion in COLO 205 human colorectal adenocarcinoma cells. The EC50 for this effect is less than 0.5ng/ml.
2μg (R: reducing condition, N: non-reducing condition).
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