Leu25-Gln167, with C-terminal Human IgG1 Fc
55-65 KD (Reducing)
PBS, pH7.4, 5%海藻糖
快速离心后根据规格取相应体积的超纯水溶解为1mg/ml的浓度。
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
PD-1(programmed death 1)程序性死亡受体1，是一种重要的免疫抑制分子，为免疫球蛋白超家族，是一个268氨基酸残基的膜蛋白。以PD-1为靶点的免疫调节对抗肿瘤、抗感染、抗自身免疫性疾病及器官移植存活等均有重要的意义。其配体PD-L1也可作为靶点，PD-1和PD-L1结合启动T细胞的程序性死亡，使肿瘤细胞获得免疫逃逸。 本产品系由HEK293细胞株表达的人源PD-1，融合了human IgG1 Fc的重组蛋白，经多步纯化后除菌过滤、添加5%海藻糖、冻干制成。
Immobilized PD-L1 His Tag, Human (Cat. No. 010001) at 2.8μg/mL (100μL/well) can bind PD-1 Fc Chimera, Human (Cat. No. 010002) with an EC50 of 4.33-5.70µg/mL.
Immobilized Biotinylated PD-L2 Avi&His Tag Protein, Human (Cat. No. UA010568) at 1.0μg/mL (100μL/well) on streptavidin precoated (0.5 μg/well) plate can bind PD-1 Fc Chimera Protein, Human (Cat. No. UA010002) with EC50 of 2.83-4.59 ng/mL.
Immobilized Biotinylated PD-L1 Avi&His Tag Protein, Human (Cat. No. UA010541) at 1.0μg/mL (100μL/well) Streptavidin precoated(0.5ug/well) can bind PD-1 Fc Chimera Protein, Human (Cat. No. UA010002) with EC50 of 4.31-7.26ng/mL.
PD-L1 His Tag, Human (Cat. No. UA010001) captured on CM5 chip via anti-His antibody, can bind PD-1 Fc Chimera, Human (Cat. No. UA010002) with an affinity constant of 0.1836 μM as determined in a SPR assay (Biacore T200)
Loaded PD-1 Fc Chimera, Human (Cat. No. UA010002) on Protein A Biosensor, can bind PD-L1 His Tag, Human (Cat. No. UA010001) with an affinity constant of 1.3 μM as determined in BLI assay.
Anti-His antibody Immobilized on CM5 Chip captured PD-L2/B7-DC His Tag, Human (Cat. No. UA010312), can bind PD-1 Fc Chimera, Human (Cat. No. UA010002) with an affinity constant of 87.22 nM as determined in SPR assay.
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