Gln26-Pro651, with C-terminal 10*His
QSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPGGGSGGGSHHHHHHHHHH
表达宿主
HEK293
分子量
87-101kDa
纯度
>95% by SDS-PAGE
内毒素含量
<0.1EU/μg
标记
Unconjugated
标签
His Tag
性状
Lyophilized Powder
缓冲体系
PBS, pH7.4
溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
12 months from date of receipt, -20 to -70 °C as supplied; 6 months, -20 to -70 °C under sterile conditions after reconstitution; 1 week, 2 to 8 °C under sterile conditions after reconstitution; Please avoid repeated freeze-thaw cycles.
文献引用
1、Segers V F M. et al. (2020) The role of ErbB4 in cancer. Cell Oncol. 43: 335-352.
2、Xu J. et al. (2018) ERBB4 promotes the proliferation of gastric cancer cells via the PI3K/Akt signaling pathway. Oncol Rep 39: 2892-2898.
稀释度
背景介绍
HER4, also known as ErbB4, is a member of epidermal growth factor receptor (EGFR) or ErbB family. The HER4 gene is localized on chromosome 2q33.3–34. HER4 is necessary for normal development of body systems including heart, nervous system, and mammary gland. HER4 is commonly expressed in many human tissues, both adult and fetal. EGFR/ErbB1/HER1, ErbB2/HER2, ErbB3/HER3, and ErbB4/HER4 are members of this receptor tyrosine kinase family. HER4 is the only member of this family of receptors with growth inhibiting properties. HER4 can activate related genes in the nucleus when combined with epidermal growth factor (EGF), promoting cell division and proliferation. It is activated through ligand binding and activates MAPKs and PI3K/AKT pathways. Her4 promotes glycolysis, glutaminolysis, mitochondrial biogenesis & OXPHOS through c-Myc-dependent signaling axis in cancer. The Her4-mediated metabolic reprogramming may in part cooperate to promote tumorigenesis in certain cancers.
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