28-36 kDa (Reducing)
Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation .
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
PD-1(programmed death 1)程序性死亡受体1，是一种重要的免疫抑制分子，为免疫球蛋白超家族，是一个268氨基酸残基的膜蛋白。以PD-1为靶点的免疫调节对抗肿瘤、抗感染、抗自身免疫性疾病及器官移植存活等均有重要的意义。其配体PD-L1也可作为靶点，PD-1和PD-L1结合启动T细胞的程序性死亡，使肿瘤细胞获得免疫逃逸。 本产品系由HEK293细胞株表达人源PD-1，C-6His重组蛋白，经多步纯化后过滤、添加5%海藻糖、分装冻干制成。
Immobilized PD-1 His Tag, Human (Cat. No. UA010004) at 1.5μg/mL (100μL/well) can bind PD-L1 Fc Chimera, Human (Cat. No. UA010003) with an EC50 of 0.141-0.174µg/mL.
Immobilized PD-1 His Tag, Human (Cat. No. UA010004) at 0.5μg/mL (100μL/well) can bind Nivolumab (starter-bio, Cat. No. S0B0566) with EC50 of 2.24-2.98 ng/mL.
Immobilized PD-1 His Tag, Human (Cat. No. UA010004) at 0.5μg/mL (100μL/well) can bind Pembrolizumab (starter-bio, Cat. No. S0B0233) with EC50 of 1.28-1.49 ng/mL.
PD-1 His Tag, Human (Cat. No. UA010004) captured on CM5 chip via anti-His antibody, can bind PD-L1 Fc Chimera, Human (Cat. No. UA010003) with an affinity constant of 0.6644 μM as determined in a SPR assay (Biacore T200).
Loaded PD-L1 Fc Chimera, Human (Cat. No. UA010003) on Protein A Biosensor, can bind PD-1 His Tag, Human (Cat. No. UA010004) with an affinity constant of 1.6 μM as determined in BLI assay.
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