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SIRP-α Fc Chimera Protein, Human

SIRP-α Fc Chimera Protein, Human

货号: UA010005
价格: 800
规格: 25μg
介绍: -
其他: -
产品规格

  • 物种

    Human

  • 分子别名

    SIRP-α Fc Chimera protein ;BIT, BITbrain-immunoglobulin-like molecule with tyrosine-based activation motifs, Brain Ig-like molecule with tyrosine-based activation motifs, CD172 antigen-like family member A, CD172a antigen, CD172a, Inhibitory receptor SHPS-1, Macrophage fusion receptor, MFR, MFRtyrosine phosphatase SHP substrate 1, MyD-1 antigen, MYD1, MYD-1, P84, protein tyrosine phosphatase, non-receptor type substrate 1, PTPNS1, SHP substrate 1, SHPS1, SHPS-1, SHPS1CD172A, signal-regulatory protein alpha, Signal-regulatory protein alpha-1, Signal-regulatory protein alpha-2, Signal-regulatory protein alpha-3, SIRP alpha, SIRPA, SIRPalpha, Sirp-alpha-1, SIRPalpha2, Sirp-alpha-2, Sirp-alpha-3, SIRPtyrosine-protein phosphatase non-receptor type substrate 1

  • Accession

    P78324

  • 表达序列

    Glu31-Arg370, with C-terminal Human IgG1 Fc

  • 表达宿主

    HEK293

  • 分子量

    70~80 kDa(Reducing)

  • 纯度

    ＞95%, by SDS-PAGE under reducing conditions

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    Human Fc Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.2, 5% trehalose

  • 溶解方法

    Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation .

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

  • 稀释度

背景介绍

  • Protein tyrosine phosphatases (PTPases) SHP-1 and SHP-2 are critical regulators in the intracellular signaling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP-2 is a signal transducer for several receptor tyrosine kinases and cytokine receptors. A novel SHP-2 associated glycoprotein was recently cloned from human, rat, mouse and cattle by several labs and was designated SIRPalpha, SHPS-1, MyD-1, BIT and p84. SIRPalpha is a new gene family containing at least fifteen members. SIRPalpha is a substrate of many activated tyrosine kinases such as insulin receptor, EGFR, PDGFR and src, and a specific docking protein for SHP-2. SIRPalpha has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion and plays a general role in different physiological and pathological processes.

  • 生物活性JSON

    • Immobilized CD47 His Tag, Human (Cat. No. UA010014) at 1μg/mL (100μL/well) can bind SIRP-α Fc Chimera, Human(Cat. No. UA010005) with EC50 of 4.51-7.55 ng/mL.
    • Anti-His antibody Immobilized on CM5 Chip captured CD47 His tag, Human (Cat. No. UA010014), can bind SIRP-α Fc Chimera, Human(Cat. No. UA010005) with an affinity constant of 3.151 nM as determined in SPR assay.

    • Immobilized SIRP-α Fc Chimera, Human (Cat. No. UA010005) at 2.0μg/mL (100μL/well) can bind Biotinylated CD47 Fc&Avi Tag, Human (Cat. No. UA010444) with EC50 of 45.92-64.38 ng/mL. 

  • 电泳JSON

    • SIRP-α Fc Chimera, Human，2μg on SDS-PAGE under Non-reducing and reducing condition. The purity is greater than 95%.

  • ELISA

    • Immobilized SIRP-α Fc Chimera Protein, Human (Cat. No. UA010014) at 2.0μg/mL (100μL/well) can bind CD47 His Tag Protein, Human (Cat. No. UA010014) with EC50 of 0.77-0.97ng/mL.