Leu29-Pro245, with C-terminal His Tag
38-48 kDa(Reducing )
PBS pH7.2, 5% trehalose
Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation .
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
B7 homolog 3 (B7-H3, CD276) is a member of the B7 family of cell surface ligands that regulate T cell activation and immune responses. B7-H3 protein contains two extracellular Ig-like V-type domains and two IgG-like C2-type domains, a transmembrane domain, and a short intracellular domain . Early research examining the biological process of B7-H3 suggested that B7-H3 is a positive regulator of T cell response . Subsequent research studies indicated that B7-H3 is a negative regulator of T cell response, and that the protein inhibits T cell proliferation . One possibility is that B7-H3 interacts with two distinct sets of receptors, resulting in seemingly opposite biological outcomes . B7-H3 is expressed by antigen presenting cells, activated T cells, and a few normal tissues, including placenta and prostate . Expression of B7-H3 is seen in several cancer types, including prostate, breast, colon, lung, and gastric cancers, and in endothelial cells from tumor associated vasculature.
Immobilized B7-H3/CD276 His Tag, Human(Cat. No. UA010010) at 2.0μg/mL (100μL/well) can bind Anti-Human B7-H3 Monoclonal Antibody (Enoblituzumab)with EC50 of 2.81-3.81 ng/mL.
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