您现在的位置： 首页   -  产品中心   -  免疫学   -   抗体
PD-L2/B7-DC His Tag Protein, Human

PD-L2/B7-DC His Tag Protein, Human

货号: UA010312
价格: 2300
规格: 100μg
介绍: -
其他: -
产品规格

  • 物种

    Human

  • 分子别名

    PDL2, PD-L2, Butyrophilin B7-DC, CD273, PDCD1 ligand 2, PDCD1L2, PDCD1LG2

  • Accession

    Q9BQ51

  • 表达序列

    Leu20-Pro219, with C-terminal 8*His LFTVTVPKELYIIEHGSNVTLECNFDTGSHVNLGAITASLQKVENDTSPHRERATLLEEQLPLGKASFHIPQVQVRDEGQYQCIIIYGVAWDYKYLTLKVKASYRKINTHILKVPETDEVELTCQATGYPLAEVSWPNVSVPANTSHSRTPEGLYQVTSVLRLKPPPGRNFSCVFWNTHVRELTLASIDLQSQMEPRTHPGGGSHHHHHHHH

  • 表达宿主

    HEK293

  • 分子量

    35-50kDa

  • 纯度

    >95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1、Kojima M. et al. (2014) Fusion Protein of Mutant B7-DC and Fc Enhances the Antitumor Immune Effect of GM-CSF-secreting Whole-cell Vaccine. J Immunother. 37(3): 147-154.

  • 稀释度

背景介绍

  • B7-DC [also known as programmed death ligand 2 (PD-L2)] is a costimulatory molecule expressed predominantly on dendritic cells (DCs) and macrophages. In addition to its coinhibitory receptor, programmed death receptor 1 (PD-1), evidence suggests that B7-DC interacts with an unidentified costimulatory receptor on T cells. B7-DC mutants with selective binding capacity for the costimulatory receptor may be effective in stimulating antitumor immune responses, while avoiding the inhibitory effects of PD-1.

  • 电泳JSON

    • 1μg (R: reducing conditions, N: non-reducing conditions).

  • SPR

    • Anti-His antibody Immobilized on CM5 Chip captured PD-L2/B7-DC His Tag, Human (Cat. No. UA010312), can bind PD-1 Fc Chimera, Human (Cat. No. UA010002) with an affinity constant of 87.22 nM as determined in SPR assay.