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FGL2 His Tag Protein, Cynomolgus

FGL2 His Tag Protein, Cynomolgus

货号: UA010363
价格: 3040
规格: 100μg
介绍: -
其他: -
产品规格

  • 物种

    Cynomolgus

  • 分子别名

    FGL2, T49, pT49

  • Accession

    A0A2K5WID3

  • 表达序列

    Pro204-Pro439, with C-terminal 8*His PVQHLIYKDCSDYYAIGKRSSETYRVTPDPKNRSFEVYCDMETMGGGWTVLQARLDGSTNFTRTWQDYKAGFGNLRREFWLGNDKIHLLTKSKEMILRIDLEDFNGVKLYALYDQFYVANEFLKYRLHVGNYNGTAGDALRFNKHYNHDLKFFTTPDKDNDRYPSGNCGLYYSSGWWFDACLSANLNGKYYHQKYRGVRNGIFWGTWPGVSEAHPGGYKSSFKEAKMMIRPKHFKPGGGSHHHHHHHH

  • 表达宿主

    HEK293

  • 分子量

    36-42kDa

  • 纯度

    >95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1、Feng Y. et al. (2020) Fibrinogen-Like Protein 2 (FGL2) is a Novel Biomarker for Clinical Prediction of Human Breast Cancer. Med Sci Monit. 26: e923531.

    2、Hou X. et al. (2021) Regulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu. Commun Biol. 4(1): 499.

  • 稀释度

背景介绍
  • Fibrinogen-like protein 2 (FGL2) is a member of the fibrinogen-like protein family and possesses important regulatory functions in both innate and adaptive immune responses. Fibrinogen-like protein 2 (FGL2) exists in both soluble and membrane forms. Soluble fibrinogen-like protein 2 (sFGL2) has been recently identified as a novel effector molecule of Tregs and plays a pivotal role in regulating both innate and adaptive immunity. FGL2 mediates its immunosuppressive activity by binding to inhibitory FcγRIIB (CD32B) receptors expressed by antigen presenting cells (APC), including dendritic cells (DC) and B cells, and thus sFGL2 may inhibit the maturation of DC, resulting in the suppression of effector T cell responses and inducing apoptosis of B cells.

  • 生物活性JSON

    • Fc γ RIIB/CD32b His Tag, Human (Cat. No. UA020003) Immobilized on CM5 Chip can bind FGL2 His Tag, Cynomolgus (Cat. No. UA010363) with an affinity constant of 0.54 μM as determined in SPR assay.

  • 电泳JSON

    • 1μg (R: reducing condition, N: non-reducing condition).