1、Freed D M. et al. (2017) EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics. Cell. 171(3):683-695.
2、Kochupurakkal B S. et al. (2005) Epigen, the last ligand of ErbB receptors, reveals intricate relationships between affinity and mitogenicity. J Biol Chem. 280(9): 8503-8512.
Epigen, human (EPGN) is a member of the epidermal growth factor family. EPGN is ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. EPGN Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases. The precursor of EPG is a widely expressed transmembrane glycoprotein that undergoes cleavage at two sites to release a soluble EGF-like domain. EPGN might represent the last EGF-like growth factor and define a category of low affinity ligands, whose bioactivity differs from the more extensively studied high affinity ligands. Recombinant EPGN is expressed by Escherichia coli, composed of 72 (Ala24-Ala95) amino acids.
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