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FGF-21 Protein, Mouse

货号: UA040070

价格: 780

规格: 10μg

介绍: -

其他: -

产品规格

物种

Mouse
分子别名

FGF-21, Fibroblast growth factor 21
Accession

Q9JJN1
表达序列

Ala29-Ser210
表达宿主

E.coli
分子量

20kDa
纯度

>95% by SDS-PAGE & RP-HPLC
内毒素含量

<1EU/μg
活性

EC50 < 0.8μg/ml
标记

Unconjugated
标签

No Tag
性状

Lyophilized Powder
缓冲体系

20mM PB, 150mM NaCl, pH 7.4
溶解方法

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
文献引用

1、Kharitonenkov A J. et al. (2005) FGF-21 as a novel metabolic regulator. J Clin Invest. 115(6): 1627-1635.
2、Guo A. et al. (2020) Sarcopenic obesity: Myokines as potential diagnostic biomarkers and therapeutic targets? Exp Gerontol. 139: 111022.
3、Gomarasca M. et al. (2020) Myokines: The endocrine coupling of skeletal muscle and bone. Adv Clin Chem. 94: 155-218.

背景介绍

Fibroblast Growth Factor 21(FGF-21) is a member of the fibroblast growth factor (FGF) family and it is involved in the modulation of cell proliferation, growth, and differentiation as well as cell metabolism. This protein is a secreted endocrine factor that functions as a major metabolic regulator, and stimulates the uptake of glucose in adipose tissue. FGF21 binds to FGFR1c complexed with β-Klotho expressed in adipocytes to activate the canonical FGF signaling pathway (ERK1/2) and the AMPK/PGC1α pathway. Therefore, FGF-21 is being pursued as a therapeutic target for diabetes and obesity.