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FGF-1 Protein, Mouse

FGF-1 Protein, Mouse

货号: UA040089
价格: 450
规格: 10μg
介绍: -
其他: -
产品规格

  • 物种

    Mouse

  • 分子别名

    FGF-1, Acidic fibroblast growth factor(aFGF), Heparin-binding growth factor 1(HBGF-1)

  • Accession

    P61148

  • 表达序列

    Phe16-Asp155

  • 表达宿主

    E.coli

  • 分子量

    17-18kDa

  • 纯度

    >95% by SDS-PAGE

  • 内毒素含量

    <1EU/μg

  • 活性

    < 0.5ng/ml

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    20mM PB, 150mM NaCl, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1、Zakrzewska M. et al. (2008) FGF-1: from biology through engineering to potential medical applications. Crit Rev Clin Lab Sci. 45(1): 91-135.

    2、Pye D A. et al. (2000) Regulation of FGF-1 mitogenic activity by heparan sulfate oligosaccharides is dependent on specific structural features: differential requirements for the modulation of FGF-1 and FGF-2. Glycobiology. 10(11): 1183-1192.

  • 稀释度

背景介绍

  • Fibroblast growth factor 1 (FGF-1), known as acidic fibroblast growth factor (FGF-Acidic), is one of the best characterized members of the FGF superfamily. FGF-1 is a powerful mitogen exhibiting strong action on numerous different cell types. It plays a role in various stages of development and morphogenesis, as well as in angiogenesis and wound healing processes. FGF-1 is released extracellularly as a disulfide-linked homodimer and is stored in complex with extracellular heparan sulfate. The association of FGF-1 with heparan sulfate is a prerequisite for its subsequent interaction with FGF receptors. Ligation triggers receptor dimerization, transphosphorylation, and internalization of receptor/FGF complexes.

  • 生物活性JSON

    • Measured in a cell proliferation assay using Balb/c 3T3 mouse fibroblast cells. The EC50 for this effect is less than 0.5ng/ml.

  • 电泳JSON

    • 1μg (R: reducing condition, N: non-reducing condition).