Gly81-Ala210
15kDa
20mM Tris, 500mM NaCl, pH8.0
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Neurotrophin 4 (NT-4) is a neurotrophic factor which supports the survival and outgrowth of sensory neurons from embryonic chicken dorsal root ganglia, but has no significant effect on embryonic day 8 sympathetic ganglia1. It has a strong survival/proliferative action on NIH 3T3 cells expressing trkB but little activity on 3T3 cells expressing trkA. NT-4 was originally identified in Xenopus and viper, and was subsequently identified in rat and humans. Neurotrophin 4 is the least studied member of the neurotrophin family. Genetic knockout of NT4 does not result in loss of any DRG sensory neurons, although this factor does influence survival of spinal motor neurons. NT4 is expressed in muscle, and its expression is regulated by activity of innervating motor neurons, which increase its production, thereby providing trophic support to those innervating neurons. This provides an excellent example of bidirectional communication between the target and the afferent neurons, in which the activity of the innervating neurons and the release of trophic factor from the target influence each other to fine-tune the synaptic connections.
Protein A Chip captured TrkB Fc Chimera, Human (Cat. No. UA010111), can bind NT-4, Human (Cat. No. UA040069) with an affinity constant of 0.27nM as determined in SPR assay.
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