1、Wodarski K. et al. (2009) Leptin as a modulator of osteogenesis. Ortop Traumatol Rehabil. 11(1): 1-6.
2、Tezapsidis N. et al. (2009) Leptin: a novel therapeutic strategy for Alzheimer's disease. J Alzheimers Dis. 16(4): 731-740.
3、Cai C. et al. (2009) Leptin in non-autoimmune inflammation. Inflamm Allergy Drug Targets. 8(4): 285-291.
4、Fernndez-Riejos P. et al. (2010) Role of leptin in the activation of immune cells. Mediators Inflamm. 2010: 568343.
5、Kelesidis T. et al. (2010) Narrative review: the role of leptin in human physiology: emerging clinical applications. Ann Intern Med. 152(2): 93-100.
Leptin (LEP) is a 16kDa peptide hormone produced mainly by white adipocyte tissue. Leptin is involved in maintaining gastric epithelial cell integrity and gastroprotection. In rats, systemic leptin is effective in attenuating both ethanol- and aspirin-induced damage to the gastric mucosa. This is correlated with an increase of leptin production by the stomach during experimentally-induced gastric damage in rats and during H pylori infection in humans. This gastric cytoprotective effect of leptin involves an increase in blood flow, local production of nitric oxide and prostaglandin E2, and vagus nerve-dependent mechanisms. One of the important functions of leptin is its role in the regulation of inflammatory processes. There is indeed a large body of evidence that leptin-mediated signal pathways play an active role in innate and adaptive immunity through alteration of various target genes transcription.
Measured in a cell proliferation assay using LOVO cells, The EC50 for this effect is less than 5μg/ml.
| 2μg (R: reducing condition, N: non-reducing condition). |
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