Biotinylated Fc γ RIIIa/CD16a(F176) Avi&His Tag Protein, Human
货号: UA010425
价格: 2970
规格: 25μg
介绍: -
其他: -
产品规格
物种
Human
分子别名
Fc γ RIIIa, CD16a, FcR-10
Accession
P08637-1
表达序列
Gly17-Gln208, with C-terminal Avi & 8*His Tag
GMRTEDLPKAVVFLEPQWYRVLEKDSVTLKCQGAYSPEDNSTQWFHNESLISSQASSYFIDAATVDDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVFKEEDPIHLRCHSWKNTALHKVTYLQNGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLFGSKNVSSETVNITITQGLAVSTISSFFPPGYQGGGSGLNDIFEAQKIEWHEHHHHHHHH
表达宿主
HEK293
分子量
45-53kDa
纯度
>95% by SDS-PAGE
内毒素含量
<0.1EU/μg
标记
Biotin
标签
Avi Tag, His Tag
性状
Lyophilized Powder
缓冲体系
PBS, pH7.4
溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
文献引用
1、Nimmerjahn F. et al. (2006) Fcgamma receptors: old friends and new family members. Immunity J. 24(1): 19-28.
稀释度
背景介绍
Fc gamma RIIIa is a low/intermediate affinity receptor for polyvalent immune-complexed IgG. It is involved in phagocytosis, secretion of enzymes and inflammatory mediators, antibody-dependent cytotoxicity and clearance of immune complexes. In humans, it is a 50-70 kDa type I transmembrane activating receptor expressed by NK cells, T cells, monocytes, and macrophages. A single nucleotide polymorphism creates high binding (V176) and low binding (F176) forms that, when homozygous, may influence susceptibility to autoimmune diseases or response to therapeutic IgG antibodies. Aberrant expression or mutations of CD16a is implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia.
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