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TNFRSF10B/TRAIL R2 His Tag Protein, Mouse

TNFRSF10B/TRAIL R2 His Tag Protein, Mouse

货号: UA010509
价格: 2050
规格: 100μg
介绍: -
其他: -
产品规格

  • 物种

    Mouse

  • 抗原名称

    TNFRSF10B/TRAIL R2

  • 分子别名

    TNFRSF10B,TRAILR2,TRAIL-R2,CD262,DR5,KILLER,TRICK2,ZTNFR9,TRICKB

  • Accession

    Q9QZM4

  • 表达序列

    Asn53-Ser177, with C-terminal 8*His NPAHNRPAGLQRPEESPSRGPCLAGQYLSEGNCKPCREGIDYTSHSNHSLDSCILCTVCKEDKVVETRCNITTNTVCRCKPGTFEDKDSPEICQSCSNCTDGEEELTSCTPRENRKCVSKTAWASGGGSHHHHHHHH

  • 表达宿主

    HEK293

  • 分子量

    20-33kDa

  • 纯度

    >95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Walczak, H. et al. (1997) EMBO J. 16:5386.

  • 稀释度

背景介绍

  • TNFRSF10B, also called TRAIL R2 and DR5, is a member of the TNF receptor superfamily. TRAIL-R2 contains two extracellular cysteine-rich repeats, typical for TNF receptor (TNFR) family members, and a cytoplasmic death domain. TNFRSF10B / DR-5 is widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines. Human and mouse TRAIL R2 share 49% amino acid sequence similarity. Some studies have suggested that TNFRSF10B contributes more than TNFRSF10A (TRAIL R1) to TRAIL-induced apoptosis in cancer cells that express both receptors. In addition, agonistic monoclonal antibodies against TNFRSF10B, which can induce apoptosis in the absence of TRAIL, are used for cancer therapies.

  • 电泳JSON

    • 2μg (R: reducing condition, N: non-reducing condition).

  • ELISA

    • Immobilized TRAIL/Apo2L, Human (Cat. No. UA040039) at 2.0μg/mL (100μL/well) can bind TNFRSF10B/TRAIL R2 His Tag, Mouse (Cat. No. UA010509) with EC50 of 30.69-44.23 ng/ml.

  • SPR

    • Anti-His antibody Immobilized on CM5 Chip captured TNFRSF10B/TRAIL R2 His Tag, Mouse (Cat. No. UA010509), can bind TRAIL/Apo2L, Human (Cat. No. UA040039) with an affinity constant of 4.67nM as determined in SPR assay.