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Biotinylated BCMA His&Avi Tag Protein, Human

Biotinylated BCMA His&Avi Tag Protein, Human

货号: UA010542
价格: 2560
规格: 25μg
介绍: -
其他: -
产品规格
  • 物种

    Human
  • 抗原名称

    BCMA
  • 分子别名

    TNFRSF17, CD269, BCM, BCMA
  • Accession

    Q02223-1
  • 表达序列

    Met1-Ala54, with C-terminal His&Avi Tag MLQMAGQCSQNEYFDSLLHACIPCQLRCSSNTPPLTCQRYCNASVTNSVKGTNAGGGSHHHHHHHHGLNDIFEAQKIEWHE

  • 表达宿主

    HEK293
  • 分子量

    15-17kDa

  • 纯度

    >95% by SDS-PAGE
  • 内毒素含量

    <0.1EU/μg
  • 标记

    Biotin
  • 标签

    Avi Tag, His Tag
  • 性状

    Lyophilized Powder
  • 缓冲体系

    PBS, pH7.4
  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.
  • 文献引用

    1. Nina Shah, Ajai Chari, Emma Scott, Khalid Mezzi & Saad Z. Usmani: B-cell maturation antigen (BCMA) in multiple myeloma: rationale for targeting and current therapeutic approaches, Leukemia volume 34, pages985-1005 (2020).

  • 稀释度

背景介绍
  • BCMA (The B-cell maturation antigen), also designated as TNFRSF17, belongs to the tumor necrosis factor receptor superfamily, which is a family of cytokine receptors. BCMA is encoded by a 2.92-kb TNFRSF17 gene located on the short arm of chromosome 16 (16p13.13) and composed of 3 exons separated by 2 introns. There are four natural splice variants of human BCMA that present with different receptor binding affinities, membrane-anchoring ability, and intracellular domain signaling. BCMA main ligands are the cytokines B-cell activating factor and a proliferation-inducing ligand. The interaction between BCMA and its ligands activates the NF-κB signaling pathway that plays an important role in B-cell proliferation and maturation and is essential for the survival of long-lived bone marrow plasma cells. BCMA is expressed preferentially on mature B cells and has minimal expression on hematopoietic stem cells or other cell types. The BCMA has emerged as a central target in multiple myeloma (MM). In preclinical studies, overexpression of BCMA and the interaction with is ligand, a proliferation-inducing ligand (APRIL), was found to promote MM progression in vivo and augment MM cell growth and survival through induction of multiple signaling cascades, including protein kinase B (AKT), MAPK, and nuclear factor (NF)-κB. Additionally, BCMA has been shown to be solubilized at high levels in serum of patients with MM (sBCMA). This form of sBCMA binds to B-cell activating factor (BAFF). The role of BAFF is to stimulate normal B-cell and plasma cell development; however, this functioning is prevented when it is bound by BCMA in the serum, thereby leading to decreased polyclonal immunoglobulin levels in patients with MM.

  • 电泳JSON

    • 1μg (R: reducing conditions, N: non-reducing conditions).

  • ELISA

    • Immobilized Biotinylated BCMA His&Avi Tag, Human (Cat. No. UA010542) at 2 μg/mL on Streptavidin precoated (0.5μg/well) plate, can bind Anti-Human BCMA Monoclonal Antibody (Belantamab) with EC50 of 1.81-2.25 ng/ml.