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TNFRSF10B/TRAIL R2 Fc Chimera Protein, Human

TNFRSF10B/TRAIL R2 Fc Chimera Protein, Human

货号: UA010513
价格: 2030
规格: 100μg
介绍: -
其他: -
产品规格

  • 物种

    Human

  • 抗原名称

    TNFRSF10B/TRAIL R2

  • 分子别名

    TRAIL-R2, CD262, DR5, KILLER, TRICK2, ZTNFR9, TRICKB

  • Accession

    O14763

  • 表达序列

    Ile56-Glu182, with C-terminal Human IgG Fc ITQQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKEIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK

  • 表达宿主

    HEK293

  • 分子量

    40-45kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    Human Fc

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. Walczak, H. et al. (1997) EMBO J. 16:5386.

  • 稀释度

背景介绍

  • TNFRSF10B, also called TRAIL R2 and DR5, is a member of the TNF receptor superfamily. TRAIL-R2 contains two extracellular cysteine-rich repeats, typical for TNF receptor (TNFR) family members, and a cytoplasmic death domain. TNFRSF10B / DR-5 is widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines. Human and mouse TRAIL R2 share 49% amino acid sequence similarity. Some studies have suggested that TNFRSF10B contributes more than TNFRSF10A (TRAIL R1) to TRAIL-induced apoptosis in cancer cells that express both receptors. In addition, agonistic monoclonal antibodies against TNFRSF10B, which can induce apoptosis in the absence of TRAIL, are used for cancer therapies.

  • 电泳JSON

    • 1μg (R: reducing condition, N: non-reducing condition).

  • SPR

    • Protein A Chip captured TNFRSF10B/TRAIL R2 Fc Chimera, Human(Cat. No. UA010513), can bind TRAIL/Apo2L, Human(Cat. No. UA040039) with an affinity constant of 25.85pM as determined in SPR assay.