Met1-Leu157 MVPGEENQLVPKEDVFWRCRQNIFDEMKKKFLQIENAAEEPRVLCIIQDTTNSKTVNERITLNLPASTPVRKLFEDVANKVGYINGTFDLVWGNGINTADMAPLDHTSDKSLLDANFEPGKKNFLHLTDKDGEQPQILLEDSSAGEDSVHDRFIGPL
12 months from date of receipt, -20 to -70 °C as supplied; 6 months, -20 to -70 °C under sterile conditions after reconstitution; 1 week, 2 to 8 °C under sterile conditions after reconstitution; Please avoid repeated freeze-thaw cycles.
1. Hu Lei, Han-Zhang Xu, Hui-Zhuang Shan, Meng Liu, Ying Lu, Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia. Nat Commun. 2021 Jan 4; 12(1):51.
Ubiquitin-specific peptidase 47 (USP47) is a member of the USP subfamily of DUBs. Similaring to other USPs, USP47 regulates cellular activities by removing ubiquitin conjugates from diverse substrates and, thereby, altering their stabilities, localizations, or activities. Specifically, USP47 deubiquitinates and stabilizes MAPK, DNA polymerase β (Polβ), E-cadherin, β catenin, SNAIL, YAP, β-Trcp, and katanin-p60. Hence, USP47 is involved in cell proliferation, cell survival, DNA damage repair, NLRP3 inflammasome activation, and epithelial-mesenchymal transition. USP47 plays an important role in cancers such as gastric cancer, medulloblastoma, and colorectal cancer.
2μg (R: reducing condition, N: non-reducing condition).
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