Leu33-Val532, with C-terminal Human IgG1 Fc LVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
1. Sweeney MD, Ayyadurai S, Zlokovic BV. Pericytes of the neurovascular unit: key functions and signalling pathways. Nat Neurosci 2016; 19: 771-783. 2. Armulik A, Genove G, Mae M, et al. Pericytes regulate the blood-brain barrier. Nature 2010; 468: 557-561. 3. Daneman R, Zhou L, Kebede AA, et al. Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature 2010; 468: 562-566. 4. Makihara N, Arimura K, Ago T, et al. Involvement of platelet-derived growth factor receptor β in fibrosis through extracellular matrix protein production after ischemic stroke. Exp Neurol 2015; 264: 127-134. 5. Sakuma R, Kawahara M, Nakano-Doi A, et al. Brain pericytes serve as microglia-generating multipotent vascular stem cells following ischemic stroke. J Neuroinflammation 2016; 13: 57. 6. Nakamura K, Arimura K, Nishimura A, et al. Possible involvement of basic FGF in the upregulation of PDGFRβ in pericytes after ischemic stroke. Brain Res 2016; 1630: 98-108.
Human platelet-derived growth factor receptor, beta polypeptide (PDGFRB) is also called PDGF-R-beta and PDGFR, is receptor that binds specifically to PDGFB. PDGFRB is a tyrosine‐kinase receptor for PDGF‐B and PDGF‐D. PDGF-BB secreted by endothelial cells binds to PDGFRB on pericytes, causing the activation of downstream signaling pathways to regulate survival, migration, apoptosis, proliferation, and differentiation. PDGF-BB/PDGFRB signaling is essential for the pericytes-regulated BBB integrity in the stage of development, and adulthood. Furthermore, expression of PDGF-BB/PDGFRB is upregulated in CNS after cerebral ischemia in human and animal models, which is involved in tissue responses especially targeting vascular pericytes. The PDGFRB/EZH2 pathway is critical for promoting cardiomyocyte proliferation and heart regeneration, providing a potential target for cardiac repair.
1μg (R: reducing conditions, N: non-reducing conditions).
Immobilized PDGF-BB, Human (Cat. No. UA040014) at 1.0μg/mL (100μL/well) can bind CD140b/PDGFRB Fc Chimera, Human (Cat. No. UA010550) with EC50 of 12.20-13.62 ng/mL.
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