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ENPP3/CD203c His Tag Protein, Mouse

货号: UA010755

价格: 2800

规格: 100μg

介绍: -

其他: -

产品规格

物种

Mouse
分子别名

ENPP3, CD203c, NPP3, E-NPP3, PD-Ibeta, NPPase, PDNP3
Accession

Q6DYE8
表达序列

Arg46-Ile874, with N-terminal His Tag
表达宿主

HEK293
分子量

100-120kDa (Reducing)
纯度

＞95% by SDS-PAGE
内毒素含量

<0.1EU/μg
标记

Unconjugated
标签

His Tag
性状

Lyophilized Powder
缓冲体系

PBS, pH7.4.
溶解方法

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
文献引用

1.Yao, Wang, Han et al.[J] J Transl Med. (2023) 21 (1), 594.

背景介绍

NPP3 (CD203c, ENPP3) is a member of the human NPP family. NPP3 is expressed in multiple organs, including on epithelial and mucosal surfaces, and notably on basophils and mast cells. This protein is in fact a common marker for diagnosing allergen sensitivity with patient basophils by flow cytometry. Basophils and mast cells mediate the response to certain pathogens, as well as acute and chronic allergic reactions. Following activation, these cells release ATP, which further stimulates them in an autocrine manner. NPP3 upregulation serves to degrade ATP and suppress chronic allergic inflammation (but not the acute response).