40-45kDa (Reducing)
1. Gene ID: 608, updated on 18-Aug-2023.
B Cell Maturation Antigen (BCMA) also referred to as TNFRSF17 or CD269, is a transmembrane glycoprotein member of the tumor necrosis factor receptor (TNFR) superfamily. BCMA is a type III membrane protein containing one extracellular cysteine rich domain. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.
1μg (R: reducing condition, N: non-reducing condition).
Immobilized Anti-Human BCMA Monoclonal Antibody (Belantamab) at 2.0μg/mL (100μL/well) can bind Biotinylated BCMA/TNFRSF17 Fc&Avi Tag, Cynomolgus (Cat. No. UA010761)with EC50 of 5.07-8.15ng/mL.