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4-1BB/TNFRSF9 Fc Chimera Protein, Mouse

4-1BB/TNFRSF9 Fc Chimera Protein, Mouse

货号: UA010800
价格: 2100
规格: 100μg
介绍: -
其他: -
产品规格

  • 物种

    Mouse

  • 分子别名

    T-cell antigen ILA; ILA; 4-1BB Ligand Receptor; CD137 Antigen; CDw137; CD137; Interleukin-Activated Receptor; Homolog Of Mouse Ly63; Tumor Necrosis Factor Receptor Superfamily; Member 9; Homolog Of Mouse 4-1BB; Receptor Protein 4-1BB; T Cell Antigen ILA

  • Accession

    P20334

  • 表达序列

    Val24-Leu187, with C-terminal hIgG Fc

  • 表达宿主

    HEK293

  • 分子量

    53-63kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    Human Fc Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4.

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Melero I, et al. (2008) Multi-layered action mechanisms of CD137 (4-1BB)-targeted immunotherapies. Trends Pharmacol Sci. 29(8): 383-90. 2. Thum E, et al. (2009) CD137, implications in immunity and potential for therapy. Front Biosci. 14: 4173-88.

  • 稀释度

背景介绍

  • CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 and CD137L are expressed in different human primary tumor tissues, suggesting that they may influence the progression of tumors. The best characterized activity of CD137 is its costimulatory activity for activated T cells.

  • 电泳JSON

    • 1μg (R: reducing condition, N: non-reducing condition).

  • ELISA

    • Immobilized 4-1BB Ligand/TNFSF9 His Tag, Rat (Cat. No. UA010859) at 2.0μg/mL (100μL/well) can bind 4-1BB/TNFRSF9 Fc Chimera, Mouse(Cat. No. UA010800) with EC50 of 1.97-2.67ng/mL.

    • Immobilized 4-1BB Ligand TNFSF9 His tag Protein，Mouse at 2.0μg/mL (100μL/well) can bind 4-1BB/TNFRSF9 Fc Chimera Protein, Mouse(Cat. No. UA010800) with EC50 of 1.79-2.13ng/mL.

  • SPR

    • Protein A Chip captured 4-1BB/TNFRSF9 Fc Chimera, Mouse (Cat. No. UA010800), can bind 4-1BB Ligand/TNFSF9 His Tag, Rat (Cat. No. UA010859) with an affinity constant of 1.60nM as determined in SPR assay.