Ser26-Phe131
12kDa (Reducing)
20mM PB, 300mM NaCl, pH6.0
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
1.Cells. 2021 Nov 3;10(11):3000.
2.Front Immunol. 2018 Jun 7:9:888. eCollection 2018.
IL-13 is the signature cytokine of the type II inflammatory response. It is key player in the inflammatory response triggered either by an invading parasite or allergen. The cellular sources of IL-4 and IL-13 have been studied extensively and along with CD4 T cells, basophils, eosinophils, mast cells, and NK T cells, appropriately stimulated ILC2 cells have the ability to produce IL-4 and IL-13. IL-13 belong to the T helper 2 (Th2) cytokine family, along with IL-3, IL-5, and IL-9. These cytokines are key mediators of allergic inflammation. They have important immunomodulatory activities and exert influence on a wide variety of immune cells, such as B cells, eosinophils, basophils, monocytes, fibroblasts, endothelial cells, airway epithelial cells, smooth muscle cells, and keratinocytes.
Measured in a cell proliferation assay using TF-1 human erythroleukemic cells, the EC50 for this effect is less than 2ng/ml.
2μg (R: reducing condition, N: non-reducing condition).
Anti-His antibody Immobilized on CM5 Chip captured IL-13RA1 His Tag Protein, Mouse (Cat. No. UA011052), can bind IL-13 Protein, Mouse (Cat. No. UA040158) with an affinity constant of 2.08nM as determined in SPR assay.
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