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Biotinylated PD-1 Fc&Avi Tag Protein, Cynomolgus

Biotinylated PD-1 Fc&Avi Tag Protein, Cynomolgus

货号: UA010810
价格: 2450
规格: 25μg
介绍: -
其他: -
产品规格
  • 物种

    Cynomolgus
  • 分子别名

    PD-1; Programmed cell death protein 1; CD279; hPD-1; PDCD1; HPD-L; HSLE1; SLEB2
  • Accession

    B0LAJ3
  • 表达序列

    Leu25-Gln167, with C-terminal hIgG1 Fc+Avi tag
  • 表达宿主

    HEK293
  • 分子量

    55-72kDa (Reducing)
  • 纯度

    >95% by SDS-PAGE
  • 内毒素含量

    <1EU/μg
  • 标记

    Biotin
  • 标签

    Human Fc Tag, Avi Tag
  • 性状

    Lyophilized Powder
  • 缓冲体系

    PBS, pH7.4.
  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.
  • 文献引用

    1. Nishimura, H et al. (1996) Int. Immunol. 8:773. 2. Keir, M.E. et al. (2008) Annu. Rev. Immunol. 26:677. 3. Butte, M.J. et al. (2007) Immunity 27:111.

  • 稀释度

背景介绍
  • Programmed cell death protein 1, also known as PD-1 and CD279 (cluster of differentiation 279) or PDCD1, is a protein that in humans is encoded by the PDCD1 gene. Mature Cynomolgus monkey PD-1 consists of a 148 amino acid (aa) extracellular region (ECD) with one immunoglobulin-like V-type domain, a 24 aa transmembrane domain, and a 95 aa cytoplasmic region. The Cynomolgus monkey PD-1 ECD shares 95% aa sequence identity with the human PD-1 ECD. The cytoplasmic tail contains two tyrosine residues that form the immunoreceptor tyrosine-based inhibitory motif (ITIM) and immunoreceptor tyrosine-based switch motif (ITSM) that are important for mediating PD-1 signaling. PD‑1 is expressed on activated T cells, B cells, monocytes, and dendritic cells while. PD-L1 expression is constitutive on the same cells and also on nonhematopoietic cells such as lung endothelial cells and hepatocytes. Ligation of PD-L1 with PD-1 induces co-inhibitory signals on T cells promoting their apoptosis, anergy, and functional exhaustion.

  • 电泳JSON

    • 1μg (R: reducing condition, N: non-reducing condition).