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FLT-3L Protein, Mouse

FLT-3L Protein, Mouse

货号: UA040159
价格: 1020
规格: 10μg
介绍: -
其他: -
产品规格

  • 物种

    Mouse

  • 分子别名

    FL; FLG3L; Flt3 ligand; Flt-3 Ligand; Flt3L; FLT3LG; fms-related tyrosine kinase 3 ligand; SL cytokine

  • Accession

    P49772

  • 表达序列

    Gly27-Arg188, with C-terminal His Tag

  • 表达宿主

    HEK293

  • 分子量

    20-33kDa(Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4.

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. Cancer Res. 2009 Oct 1,69(19):7747-55.

    2. Blood, Jul 2009, 114: 835 - 843.

    3. J. Immunol., Jun 2009, 182: 7408 - 7414.

  • 稀释度

背景介绍

  • FLT-3 ligand promotes long- term expansion and differentiation of human pro-B-cells in the presence of IL-7 or in combination of IL-7 and IL-3.The human FLT-3 ligand also stimulates the proliferation of cells expressing murine FLT-3 receptors. In combination with SCF and IL-3, FLT-3 ligand can cause expansion of cells with the marker spectrum CD34(+) CD38(-). Alone, FLT-3 ligand supports the survival of precursors in the lineage of blood-forming cells such as CFU-GM, CFU- GEMM, and the very primitive high proliferative potential colony-forming cells, HPP- CFC. flt-3 ligand only has marginal effects on progenitors for erythroid cells and megakaryocytes.

  • 生物活性JSON

    • Determined by the dose-dependent stimulation of the proliferation of human OCI-AML5 cells.The EC50 for this effect is less than 3ng/ml.

  • 电泳JSON

    • 1μg (R: reducing condition, N: non-reducing condition).