1.Review Pol J Pharmacol . 2004 Jan-Feb;56(1):5-27.
Adrenomedullin (ADM) is a 52-amino acid peptide homologous to calcitonin gene-related peptide (CGRP), a member of the adrenomedullin family originally isolated from human pheochromocytoma. It plays a key role in the regulation of many physiological processes, especially those of the cardiovascular and lymphatic systems. It also can be detected in lung, ventricle and kidney tissues. ADM is expressed in a variety of tissues in the human body and is fundamentally involved in multitude biological processes. It is believed that adrenomedullin functions through combinations of the calcitonin receptor like receptor and receptor activity-modifying proteins complexes, as well as CGRP receptors.
1μg (R: reducing condition, N: non-reducing condition).