Val22-Val196
18 kDa (Reducing)
PBS, pH7.4
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
·3 months, -20 to -80℃ under sterile conditions after reconstitution.
·1 week, 2 to 8℃ under sterile conditions after reconstitution.
·Please avoid repeated freeze-thaw cycles.
Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature. 2009;461(7265):798-801.
Interferon lambda 3 (IFN-λ3), also known as interleukin-28B (IL-28B), is a type III interferon that plays a crucial role in the innate immune response against viral infections. IFN-λ3 is produced in response to viral stimuli and exerts potent antiviral effects by inducing the expression of interferon-stimulated genes (ISGs) that inhibit viral replication and spread. Similar to other type III interferons, IFN-λ3 signals through the IFN-λ receptor complex, which consists of IL-10R2 and IL-28Rα subunits, leading to the activation of downstream signaling pathways involved in antiviral defense. IFN-λ3 has been implicated in the immune response to various viral infections, including hepatitis C virus (HCV) and influenza virus, and is considered a promising therapeutic target for the treatment of viral diseases.
Measured in an anti-viral assay using HepG2 human hepatocellular carcinoma cells infected with encephalomyocarditis (EMC) virus. The EC50 for this effect is 1-3 ng/mL.
2μg (R: reducing condition, N: non-reducing condition).
>90% as determined by RP-HPLC.
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